11/10/2023 0 Comments Glims definitionTherefore, early nutritional assessment is important in patients with CD. However, nutritional treatment is not indicated in every patient, which requires nutritional screening and assessment. A meta-analysis revealed that the combination of enteral nutrition with biological agents was 2.4 times more effective in maintaining clinical remission than single treatments ( 7), suggesting that nutritional therapy plays an important role in the prognosis of patients with CD. Previous researchers have demonstrated increased risks of venous thromboembolism ( 4), Non-elective surgery ( 5), longer hospital stays ( 5), and increased mortality in malnourished patients with CD ( 6). Screening for and managing malnutrition by an appropriately trained multidisciplinary team is suggested in the European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines ( 3). Nutritional interventions may improve the outcomes of patients with CD, especially those with severe CD. Several studies have reported that 20–40% of outpatients with CD present with specific nutrient deficiencies ( 1, 2). The new criteria should be more appropriate for assessing the nutritional status of patients with CD.Ĭrohn's disease (CD) is a chronic, relapsing, inflammatory disorder of the digestive tract that can lead to protein loss due to the presence of intestinal leaks. The 6-week remission risk in patients treated with nutrition therapy was more than 4-fold higher than those without nutritional therapy.Ĭonclusion: The GLIM criteria could diagnose more malnourished patients with CD who are not positively screened by the NRS 2002, among whom nutritional support therapy would be beneficial for disease remission. Among 26 GLIM+/NRS− patients, significantly more patients who received nutritional support achieved 6-week remission than patients who did not (100 vs. The age at onset and CDAI were regarded as independent risk factors related to malnutrition, as determined by the GLIM criteria. Multivariate analysis showed that a high malnutrition risk was independently associated with the L4 phenotype and Crohn's Disease Activity Index (CDAI) based on the NRS 2002. Results: Of the 118 patients included, fifty were classified as having a high malnutrition risk according to the NRS 2002, while 76 were diagnosed with malnutrition by the GLIM criteria. A multivariable Cox hazard model was used to assess the association between nutritional therapy and prognostic outcomes. Multivariable analysis was performed to evaluate risk factors related to malnutrition in patients with CD. After bioelectrical impedance analysis, all patients underwent nutritional screening and diagnosis using the NRS 2002 and GLIM criteria, respectively. Methods: This study retrospectively enrolled patients with CD at the Gastroenterology Department of Xiangya Hospital Central South University between March 2020 and March 2021. The aims were to explore the related factors of malnutrition in CD and explore whether GLIM-positive patients who did not meet the Nutritional Risk Screening 2002 (NRS 2002) would benefit from nutritional treatment. The Global Leadership Initiative on Malnutrition (GLIM) criteria represent a new consensus for the diagnosis of malnutrition but need to be validated in CD. 3Research Center for Geriatric Disorder, Xiangya Hospital, Central South University, Changsha, Chinaīackground: The early recognition of malnutrition is essential for improving the prognosis of patients with Crohn's disease (CD).2Hunan International Scientific and Technological Cooperation Base of Artificial Intelligence Computer Aided Diagnosis and Treatment for Digestive Disease, Xiangya Hospital, Central South University, Changsha, China.1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, China.Yong Li 1,2 Ziheng Peng 1,2 Duo Xu 1,2 Yu Peng 1,2 * Xiaowei Liu 1,2,3 *
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